(+91) - 452 - 2536352

About us

image

Pandian Bio-Medical Research Centre (PBRC) is the research wing of Pandian Advanced Medical Centre Pvt Ltd (PAMC). PBRC was started in 2011 as the research lab of PAMC. The managing director of PAMC Dr S Pugalanthipandian is a consultant Ortho-Neuro surgeon and is in orthopaedic practice since 1984. Based on the vast experience in providing Trauma and Spine care more than thirty years started feeling the need of better synthetic bone substitutes and that laid the foundation for initiating a research laboratory by PAMC to focus its efforts in inventing better molecules which can be used as synthetic bone grafts.

Industrial Collaboration

PBRC is looking out of industrial collabration to take the good results of their research molecule to human use. Interested companies who are in the same line can contact for knowledge sharing and business collaboration to take this forward.

Brief Overview of Our Work

Stage 1

Initial work done was to optimise the ideal concentration of fluorine in glass to increase the bioconversion. Fluorine a bone anabolic factor is known to medical fraternity for years. Having treated patients with fluorosis where even the membranes in the body get ossified the ideal dose of fluorine which will promote bone formation but not toxic to the human cells and tissues had to be optimised. It was found, 5% of fluorine in the glass system is nontoxic but promotes bone formation.

Stage 2

The mechanical properties of the fluorophosphate glass and bioconversion rate of the fluorophosphate glasses were studied by doping it with various concentrations of metal oxides (silver, titanium, zirconium, zinc, strontium, magnesium). The following characteristics were done for all the combinations.

  • Density of the prepared fluorophosphate glass samples were obtained using Archimede’s principle.
  • Elastic moduli of all the prepared glass samples were calculated by longitudinal and shear ultrasonic velocity measurements using ultrasonic process control system (model FUII050; Fallon Ultrasonics Inc. Ltd., Ontario, Canada), with a 100 MHz digital storage oscilloscope (model 54600B; Hewlett Packard, Palo Alto, California, U.S.A.) by adopting pulse echo method.
  • XRD pattern were obtained for each glass sample using X-ray diffractometer (PW 1700; Philips, Eindhoven, The Netherlands) to confirm the amorphous nature of prepared glasses and the existence of HAP layer on the surface of glass samples after in vitro studies.
  • Energy dispersive spectroscopy (model: X-mas 50mm2 Oxford Abingdon, England) was used to determine the experimental composition of prepared glass samples.
  • X-ray photoelectron spectrometer (model Kratos; Ultra Axis, Manchester, UK) with Al and Mg Kα dual source operating at 210W was used to conduct XPS studies.
  • The SBF solution was prepared in the laboratory using the method formulated by Kokubo et al. In vitro studies for all the prepared glass samples were done by soaking in SBF solution for 21 days in a CO2 incubator (model Heracell; Heraeus, Hanau, Germany). pH variations in the SBF solution were noted for all 21 days using a pH meter (model 5 Star; Thermo Orion, USA).
  • The scanning electron microscope (model 514A; Zeiss, Oberkochen, Germany) was used to analyse the surface morphology of all glass samples.
  • Fourier transform infrared spectra were recorded to find the functional groups in all the glass samples using FTIR spectrometer (model 8700; Shimadzu, Tokyo, Japan).