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About us

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Pandian Bio-Medical Research Centre (PBRC) is the research wing of Pandian Advanced Medical Centre Pvt Ltd (PAMC). PBRC was started in 2011 as the research lab of PAMC. The managing director of PAMC Dr S Pugalanthipandian is a consultant Ortho-Neuro surgeon and is in orthopaedic practice since 1984. Based on the vast experience in providing Trauma and Spine care more than thirty years started feeling the need of better synthetic bone substitutes and that laid the foundation for initiating a research laboratory by PAMC to focus its efforts in inventing better molecules which can be used as synthetic bone grafts.

Industrial Collaboration

PBRC is looking out of industrial collabration to take the good results of their research molecule to human use. Interested companies who are in the same line can contact for knowledge sharing and business collaboration to take this forward.

Brief Overview of Our Work

As a practising Orthopaedic surgeon for thirty two years, as the complexity of surgeries done keep increasing and challenges faced reach different heights, always felt the need for more bone graft. The need exceeds the availability of autograft and the procedure is hampered by the associated morbidity. There comes the need for bone graft substitutes.

An ideal bone graft substitute should be

  • Bioactive
  • Nontoxic (either the material or its degradation products)
  • Should prompt cell adhesion
  • Should be osteo-conductive and osteo inductive (bio convertible)
  • Should have mechanical properties matching the host bone
  • Should resorb at the same rate as new bone is formed
  • Should be angiogenic
  • Should be available in various forms
  • Should have the potential for bulk production

NONE OF THE BONE SUBSTITUTES AVAILABLE IN THE MARKET MEETS ALL THE ABOVE CRITERIA. To enhance these factors research has been going on at PBRC for the past 8 years.

The first generation of bone substitutes HAP and TCP are not bioactive. They are simply osteo-conductive and not inductive. Even after years, during revision surgeries we can see the unabsorbed HAP. Their mechanical strength doesn’t match the host bone and they are brittle and not useful for load bearing. They never promote angiogenesis.

The second generation of bone substitutes ‘the silica based bioglass’ are available in the market in various forms like, granules, putty and plates. The rate of bioconversion is slow, it takes a prolonged time for bone conversion. Mechanical strength is another pitfall with silica based glass system.

The third generation of bone substitute the silica free phosphate glasses are better than silica glass in its mechanical strength but the bioconversion is in no way superior to silica glasses. To increase the strength metal oxides at various concentrations have been added to the above systems, but the problem of toxicity arises after a limited level of doping.

At PBRC, to enhance the rate of bioconversion and have better mechanical strength we have tried various combinations of metal oxides and fluorine. We have come out with some stunning results.